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This is relevant to ANCA-associated vasculitis, where anti-MPO autoimmunity can be driven by TLR9-mediated DC activation 47 , and to nonalcoholic steatohepatitis (NASH), in which hepatocyte mitochondrial DNA triggers liver inflammation through TLR9 activation in proinflammatory cells, including neutrophils 48

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Its important to discuss any preexisting health conditions and medications with your provider

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