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In this study, the difference in body weight reduction between tirzepatide- and semaglutide-treated groups can only partly explain the improvement in insulin sensitivity, lending support to the observation that tirzepatide was associated with improvements in insulin sensitivity associated with both body weight-lowering and a potential insulin-sensitizing effects of GIP

What the evidence is preclinical actually means for a reader Preclinical means the findings come from cell cultures and animal models, not from controlled human trials

A phase 2, double-blind, placebo-controlled trial randomized patients with moderate-severe PDPN to subcutaneous fulranumab or placebo

Semaglutide (Ozempic) is a GLP-1 medication designed to support weight loss by reducing appetite, controlling cravings, and promoting sustainable fat loss

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