The DAC-specific stability note: The maleimide-lysine conjugate in CJC-1295 DAC can undergo hydrolysis at the succinimide ring under acidic or basic pH conditions, potentially releasing the DAC portion and leaving standard Mod GRF 1-29
Diabetes Obes Metab 18(4):333347 Deacon CF (2019) Physiology and pharmacology of DPP-4 in glucose homeostasis and the treatment of Type 2 diabetes
doi: 10.1300/J092v13n01_02 69 PerezMJaundooRHiltonKDel AlamoAGemayelKKlimasNGet al
However, the additional ingredients may affect the appearance of the reconstituted solution (B12 adds a pink tint, for example) and may have their own stability profiles
Kowalczyk P, Sulejczak D, Kleczkowska P, Bukowska-Oko I, Kucia M, Popiel M, et al
Despite that, your patients (and the FDA) will be talking about this a lot