Study limitations included the lack of generalizability to patients in later stages of ALS, risk of including ALS mimics, shorter treatment duration of 16 weeks vs the typical 24 weeks in other clinical trials, small sample size, and lack of evaluation of specific disease-related biomarkers
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Two separate human clinical trials (ulcerative colitis and multiple sclerosis) proceeded without significant adverse event reporting
This depends on the severity of your deficiency, but many people start with a short loading course followed by maintenance injections every few months
Some people also give themselves injections under the skin
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