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The warning specifically contraindicates Zepbound in patients with: Personal history of medullary thyroid carcinoma (MTC) Family history of MTC Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) , a hereditary condition that significantly increases MTC risk MEN 2 is an inherited disorder caused by mutations in the RET proto-oncogene, leading to increased susceptibility to MTC, pheochromocytoma, and parathyroid tumors
Of note, this approach to ICP monitoring was chosen by the patient advisory group due to the negative impact reported by repeated lumbar punctures [23, 24], and the use within the trial was carefully discussed with the individual participants during the consent process
& Tipparaju, S
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And, critically, evolving legal status that may affect long-term availability
Pleiotropic effects of the dipeptidylpeptidase-4 inhibitors on the cardiovascular system
