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Supplementation may therefore enhance mucosal health.[1,8] A healthy intestinal mucosa not only supports optimal nutrient absorption, but it also supports mucosal immune function and provides a barrier between bacteria and their products in the intestines and the bloodstream.[1,9,10] Disruption of intestinal barrier function can lead to decreases in mucosal immune activity and increases in escaping toxins and bacteria, resulting in infections, illness, allergic reactions, skin conditions, and more

The new label includes references to some of those postmarketing risks, including intestinal obstruction, [and] severe constipation including fecal impaction. Some patients who took Zepbound have filed lawsuits, accusing Eli Lilly of failing to properly warn them that Zepbound could increase their risk of severe gut problems, including bowel obstructions, pancreatitis, and gastroparesis

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The protective role of hydrogen-rich saline in experimental liver injury in mice