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For patients not responding adequately at 12 weeks on a stable maintenance dose, clinicians should verify proper administration technique, assess adherence patterns, and consider whether further dose escalation is appropriate and tolerable before concluding the medication is ineffective

This is consistent with the abolition of most of the H 2 O 2 -induced glutathione oxidation in mutants for the cytosolic isoforms (Rahantaniana et al

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