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Clinical trial data from the SURMOUNT programme shows headache reporting drops from 22% at week 4 to 8% at week 12, indicating physiological adaptation rather than persistent drug effect

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Hypersensitivity and Anaphylaxis Severe allergic reactions including angioedema and anaphylaxis have been rarely reported

Hydration and Diet Steps Vomiting drains fluids fast, and dehydration can quickly become the bigger danger

Some clinical trials are open only to patients who have not started treatment

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