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33 Although decreases in gastric emptying via GLP-1RAs help prevent overnutrition by decreasing nutrient absorption, there is concern that patients could be at risk of nutrient deficiencies driven by malabsorption from delayed gastric emptying
In the offspring, reduced growth and fetuses with visceral (heart blood vessels) and skeletal (cranial bones, vertebra, ribs) abnormalities were observed at the human exposure
The SURMOUNT-4 trial (NEJM, 2023) demonstrated that continued treatment is necessary to maintain weight loss, as participants who discontinued tirzepatide after achieving weight loss regained significant weight during the withdrawal phase
How can I tell if its die-off or a flare-up
N., Eshaa, E., Hassan, M., Chowdhury, T
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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