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The TESTING randomized controlled clinical trial consisted of 503 patients randomized with 257 in the treatment group and 246 in the placebo group

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doi: 10.3389/fendo.2019.00431 3

These have specificities for cationic residues (arginine and lysine) and aromatic residues respectively, so that most therapeutic proteins are vulnerable to attack by one or both of these enzymes

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As a result, pharmaceutical companies are investing heavily in non-injectable formulations to capitalize on this growing preference