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These consumers, as well as dermatologists who prescribe oral glutathione for general skin lightening or as an adjuvant for disorders of hyperpigmentation, are often oblivious about its efficacy, dosing and adverse effects

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6 This mechanism primarily involves the irreversible inhibition of COX enzymes, 1 particularly COX-1 and COX-2, 66 by introducing the acetylation of a specific serine residue (Ser530) in their active sites

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