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No controlled trials exist in pregnant women for ethical reasons, so the FDA's cautious approach is based on animal data plus the principle that avoidable medication exposure during pregnancy should be minimized
Curcumin, the active ingredient in turmeric, tends to be poorly absorbed by our digestive system
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For example, dulaglutide (Trulicity) is only authorised for type 2 diabetes, while semaglutide 2.4mg (Wegovy) and liraglutide 3mg (Saxenda) have specific authorisations for weight management with eligibility criteria defined by NICE guidance
GLP-1 RAs bypass genetic defects in the leptin-melanocortin system, promote weight loss, and improve metabolic function through the coordinated regulation of blood glucose and appetite [64,65] [Figure 2]
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