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GLP-1 receptors are found in several brain regions, including: The ventral tegmental area (VTA) The nucleus accumbens The prefrontal cortex When activated by GLP-1, these receptors appear to reduce the release of dopamine in response to addictive substances
This corresponds with Zhang et al
doi: 10.1016/j.tem.2016.10.005 142 DinAUHassanAZhuYYinTGregersenHWangG
For retatrutide: trials are underway along the same lines The TRIUMPH program includes equivalent pleiotropic trials for retatrutide: a sleep apnea arm (TRIUMPH-OSA), a MASLD arm (TRIUMPH-MASLD), and a cardiovascular trial (CVOT)
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