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In people with T2D, oral semaglutide 50 mg once daily resulted in 9.8% WL vs
doi:10.1053/j.gastro.2006.05.055 71 DubPEBrubakerPL
Determination of liraglutide in rat plasma by a selective liquid chromatographytandem mass spectrometry method: application to a pharmacokinetics study
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[13] These findings are further reinforced by pharmacovigilance data from the FDA Adverse Event Reporting System (FAERS) database (n=48,214 reports), where GLP-1RA-related gastrointestinal adverse events, including nausea (9651 vs 38,030) and vomiting (4383 vs 17,062), were lower with combination therapy compared to GLP-1RA monotherapy, suggesting improved tolerability when metformin is added
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