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After 48h of incubation the cells were exposed to either DMSO, diethylmaleate or diclofenac for 3, 8 or 24h

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The medications are GLP-1 receptor agonists, which mimic the effects of naturally occurring GLP-1 peptides produced in the gut

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48,49,50,51 Moreover, through the action of two of the enzymes involved in the production of H 2 Scysteine aminotransferase (CAT) and 3-mercaptopyruvate sulphurtransferase (3-MST)cysteine is sequentially converted into 3-mercaptopyruvate (3-MP) with the release of an amino group that will react with -ketoglutarate, ending with the formation of glutamate and pyruvate (Fig