Prioritize whole foods with high-quality protein, colorful vegetables, healthy fats, and a variety of textures and flavors to encourage eating even when appetite is low
for example, according to Semaglutide in the Real World: Attitudes of the Population, semaglutide was tested in 300 clinical trials, with 90% showing improved glucose regulation in patients, which explains why HbA1c and fasting glucose are the most directly affected markers
Resting Energy Expenditure and Metabolic Adaptation Following Sleeve Gastrectomy in Hispanic Adults with Obesity
It should be noted that GIPR antagonism paradoxically produces additive weight loss when paired to GLP-1R agonism in preclinical studies (5860) and that this mechanism appears relevant in patients with obesity (61)
The study concluded that there may be clinical benefit to the use of GLP1-RA in MCAS but as this was an observational study, there were no controls
However, more studies are needed to fully understand the extent of Melanotan 2s effects on these physiological processes