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[22] Additionally, a shift in the timing of melatonin secretion is observed during adolescence, resulting in delayed sleep and wake times, increasing their risk for delayed sleep phase disorder during this period

PPARs as master regulators of carnitine homeostasis Genes regulated by peroxisome proliferator-activated receptor (PPAR) are involved in many biological processes such as fatty acid catabolism, ketogenesis and gluconeogenesis, and also play a key role in the regulation of carnitine homeostasis [189]

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PMCID: PMC8475422