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Consistently with its low efficacy in beta-arrestin recruitment, which is involved in receptor endocytosis, the ability of tirzepatide to induce GLP-1R internalization is approximately 40% that of native GLP-1 while its effect on GIPR is similar to native GIP

Keep weight loss at about 0.5%1% of body weight per week rather than losing too quickly

Track ovulation signs if trying to conceive or avoid pregnancy

Storage Recommendations To help maintain peptide stability: Store unopened vials in a cool, dry location

No syringes, no pens, just a patch on your skin releasing ingredients throughout the day

Tirzepatide (Mounjaro, Zepbound) and retatrutide (Retara) are dual and triple agonists, not pure GLP-1 agonists