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This triple mechanism of action distinguishes retatrutide from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 agonist)
Sergey Terushkin, MD, FACS Starting dose: 2.5 mg weekly Dose escalation: every 4 weeks Maintenance dose: 515 mg Maximum dose: 15 mg Starting dose: 0.25 mg weekly Dose escalation: every 4 weeks Maintenance dose: 12.4 mg Maximum dose: 2.4 mg Learn More About: Tirzepatide Before and After Results: Weight Loss Timelines (2026) Compounded medications are prepared by licensed pharmacies and may be prescribed when appropriate
In: Bergmeyer HU, editor
Real results from Shed members Our clinical team supports you from day one, and it shows
GLP-1RAS use did not significantly reduce the risk of osteoporotic fractures
Many women also explore our GLP-1 strength training programs for adults over 40 to better understand how resistance training protects muscle and bone density during rapid weight loss
