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Several preclinical experiments examined how BV affects leukocyte migration and microglial activation in animal and cellular models (Avalo et al., 2022

Clinical practice guidelines suggest several scenarios where dose modification may be appropriate: Persistent gastrointestinal symptoms lasting beyond the first week of a new dose level may warrant extending that dose phase by an additional 2-4 weeks before further escalation

Pain during gripping activities, weakness in the affected arm, and decreased function can persist for months or even years

Consider factors such as your current Vitamin B12 levels, dietary habits, and any existing health concerns

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doi:10.1016/j.clnu.2017.07.008