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The effects are produced mainly by the increase in nitric oxide (NO), cyclic AMP (cAMP), mitogen-activated protein kinases (MAPKs), matrix metalloproteinases (MMPs), angiogenic growth factors like vascular endothelial growth factor (VEGF) and upregulating the expression of endothelial-B receptor (ET-B) [12]
Deisseroth K, Singla S, Toda H, Monje M, Palmer TD, Malenka RC
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Both interventions produce side effects individually
Morning injections tend to reduce hunger throughout the day, while evening injections may suppress evening appetite and cravings
No standardized human dosing exists, and individual responses vary considerably
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