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Aim for a minimum of 64 ounces of water daily, increasing to 80 to 100 ounces if you exercise

Physiol Behav 100 , 503510, (2010)

The clinical data at this dose is robust

Zhong Nan da Xue Xue Bao Yi Xue Ban

On the flip side, what this trial saw was a massive reduction of muscle mass and about half of the participants who were on the drug, re-gained the weight back within the next consecutive two years