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Nausea affects approximately 25% of users at therapeutic doses, making it the most common complaint

But a drug that eases symptoms in one person may make them worse in another, or a drug that works for a while may stop working

Under the agreement, Ascendis will receive up to US$285m in upfront, development, and regulatory milestone payments for the lead programme, along with sales-based milestone payments and tiered royalties

This attentive oversight allows adjustments to be made thoughtfully, ensuring that therapy remains aligned with both health goals and tolerability

In 2022, Mounjaro was FDA-approved to treat type 2 diabetes

(3) Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI