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One outcome is the accumulation of the oncometabolite -ketoglutarate, feeding the production of citrate and acetyl-CoA

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It ensures mitochondria are efficient, DNA is repaired, and sirtuins are active

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for 4 weeks, has also shown benefit alongside pregabalin (a drug commonly used for neuropathic pain), but as this was an uncontrolled trial the contribution B12 made to the improvements cannot be established

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