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59,60 Specific genes implicated include vascular endothelial growth factor (VEGF), neurotrophic receptor tyrosine kinase 1, sodium voltage-gated channel alpha subunit 2 (SCN2A), angiotensin-converting enzyme, and methylenetetrahydrofolate reductase, with polymorphisms associated with increased DN susceptibility
however, its amount diminishes with poor diet, stress, infection and exposure to toxins, pollution, and radiation
These situations require patience and sustained support rather than aggressive intervention
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