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Studies show that NNMT inhibition by 5-amino-1-methylquinolinium significantly reduces nicotinamide metabolism, increases NAM accumulation, improves NAD+ synthesis efficiency by over 30%, and markedly increases mitochondrial ATP production and cellular energy metabolism

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10.1016/j.npep.2017.12.002 18 CoriatR.AlexandreJ.NiccoC.QuinquisL.BenoitE.ChreauC.et al (2014)

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