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The enthusiasm for potential therapeutic use of GLP-1 derives from studies demonstrating that unlike GIP, the glucose-lowering actions of GLP-1 are preserved in patients with type 2 diabetes
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This means you eat fewer total calories, which is the goal for weight management
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Surprisingly, mice with specific genetic deletion of Gpx1 appear phenotypically normal and with normal life span (Ho et al., 1997), suggesting that there are alternative compensatory mechanisms for H 2 O 2 scavenging in Gpx1 deficiency
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