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Shin D, Narciso-Gaytn C, Park JH, Smith SB, Snchez-Plata MX, Ruiz-Feria CA

Compared with older pharmacologic options, GLP-1 receptor agonists and newer incretin-based therapies generally offer greater average weight reduction, but they also raise specific issues related to gastrointestinal tolerability, long-term continuation, affordability, and access ( 6 Safety and practical prescribing considerations in KOA patients Safety considerations are particularly important when GLP-1 receptor agonists are considered for patients with obesity-related KOA, because this population often includes older adults, patients with multimorbidity, and individuals approaching elective arthroplasty

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It is important to note that whilst these changes are statistically significant in large trials, the clinical significance for individual patients remains modest compared to dedicated lipid-lowering therapies such as statins