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Food and Drug Administration (FDA) has approved Ozempic (semaglutide) as the first and only GLP-1 receptor agonist (GLP-1 RA) specifically indicated to reduce the risk of worsening kidney disease, kidney failure, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease (CKD)
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This allows magnesium to play its cofactor role in the creation of glutathione, as described later in this article
The most relevant systematic review found 36 studies, but 35 were preclinical and only 1 was clinical, with no large human efficacy trials identified [4]
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