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After 2 weeks of acclimatization, animals were randomly assigned to the control or exposed experimental unit

Extensive research has indicated that metformin exhibits notable effectiveness in addressing PCOS-related complications, including cardiovascular diseases, MASLD, MS, and EC, underscoring its significant potential to enhance long-term health outcomes in individuals with PCOS

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When compared to GLP1RAs, which improve insulin sensitivity primarily through weight reduction, a post-doc regression analysis of HOMA2-IR indicates that only 2030% of the improvement in insulin sensitization observed with tirzepatide is due to weight loss (NCT03951753) [77, 78]

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