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This suggests that some therapeutic benefits of canagliflozin could result from the activation of AMPK, rather than inhibition of SGLT2 ( DPP-4 inhibitors These compounds, by preventing deactivation by dipeptidyl peptidase-4 (DPP4) inhibitors, improve the concentration of endogenous incretins (Vangoitsenhoven et al., 2012)
& Healy, D
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It amplifies an existing one that already determines baseline appetite in healthy populations
Evans AG, Fornasi G
Both drugs are being developed by Novo Nordisk, likely reflecting a portfolio strategy: CagriSema as the first-to-market injectable combination, and amycretin as a follow-on oral option for patients who prefer pills
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