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It depends on the type of pigmentation you are treating & other therapies that are initiated

CL Answer Can baking soda really help treat rheumatoid arthritis

This longevity of research interest is itself informative: compounds that fail to replicate across independent laboratories typically disappear from the literature within a decade

The effect of hCG and placental lactogen on lymphocyte transformation in vitro [PMID: 136039] Laboratory literature summary: The effect of hCG and placental lactogen on lymphocyte transformation in vitro

And that's because there are melanocytes simulating hormone receptors all throughout the gut

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