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SQOR catalyzes the first and rate-limiting step in mitochondrial H 2 S oxidation by transferring electrons from sulfide to ubiquinone (CoQ 10 ), forming ubiquinol (CoQ 10 H 2 ) and a persulfide intermediate, which is further metabolized by downstream enzymes in the sulfide oxidation pathway 46,47

Similarly, CPUY192018, a potent small-molecule inhibitor of the Keap1-Nrf2 PPI, demonstrated cytoprotective effects in NCM460 colonic cells and a DSS-induced UC model by activating Nrf2 signaling (262)

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doi: 10.3389/fendo.2025.1620230 49 HuangYLiSLiWZhangTLuZLiCet al