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Key outcomes: Mean weight loss: 14.9% (vs 2.4% placebo) 86.4% of participants achieved 5% loss (vs 31.5% placebo) 50.5% achieved 15% loss (vs 4.9% placebo) SELECT (Lincoff et al., NEJM 2023) added the cardiovascular signature: in 17,604 non-diabetic adults with prior CV history, semaglutide 2.4 mg reduced MACE (CV death, MI, stroke) by 20% over 3 years
Bile acid stimulates GLP-1 secretion from GLUTag cells in a GPBA-R dependent manner
This ended the legal pathway that allowed 503B outsourcing facilities to produce bulk compounded semaglutide as "essentially a copy" of the brand-name drug
Ozempic is the most consistently covered product (for diabetes) across provincial formularies
This allows the antioxidant to enter the bloodstream without relying on digestive absorption
Lab tested for quality and safety
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