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Peyronies Disease is a medical condition where fibrous scar tissue develops on the penis, causing it to bend or curve during erections

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The initial model was rigid-body fitted into the consensus EM density map via UCSF Chimera 1.14 32 , followed by manual adjustment using ISOLDE 33 embedded in UCSF ChimeraX 1.6 34

Regulatory hurdles: Approval for novel indications (Alzheimers, neurodegenerative diseases) requires very high bar: long follow-ups, clinically meaningful endpoints, safety

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