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Studies have shown that all 15 GLP-1 medications significantly reduce HbA1c and fasting blood glucose levels compared to placebo

HOMAIR, homeostatic model assessment of insulin resistance

Notably, in the Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND) trial comparing dulaglutide to placebo, there was an 11% reduction in the incidence of a sustained decline in eGFR of 30% (HR, 0.89

On GLP-1 medications where transit time is already extended, the ceiling for comfortable fiber intake may be lower than for the general population

References Roberts CK, Hevener AL, Barnard RJ: Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training

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