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They are not FDA-approved, which means they have not undergone FDA review for safety, efficacy, or manufacturing quality
It has been shown that GLP-1RA semaglutide can improve working and spatial memory in transgenic AD modelling APP/PS1/tau (3xTg) mice, promote the release of anti-inflammatory factors and inhibit the production of pro-inflammatory factors in the cerebral cortex and hippocampus, as well as reduce the deposition of -amyloid in the CA1 subfield of the hippocampus
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Therefore, saxagliptin should not be used in patients with heart failure
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A 2025 cohort study of nearly 58,000 GLP-1 users found that people who actively engaged with a digital tracking tool lost noticeably more weight about 9.0% versus 5.9% at three months, and 11.5% versus 8.0% at five months than those who did not
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