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In a 2-year carcinogenicity study in Sprague Dawley rats, subcutaneous doses of 0.0025, 0.01, 0.025 and 0.1 mg/kg/day were administered (below quantification, 0.2-, 0.5-, and 3-fold the exposure at the MRHD)
Bailes J, Soloviev M
In Phase 2 clinical trials, retatrutide was administered as a once-weekly subcutaneous injection using a structured dose-escalation schedule to improve gastrointestinal tolerability
SPF 30 or higher, reapplied every two hours during outdoor activity, is essential
Burke, J
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