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This long duration of action is one of the reasons it has generated so much attention in the weight loss research community

However, for those whose jobs demand unconventional schedules, maximizing the quality of available sleep time represents a reasonable harm reduction strategy

doi: 10.1016/j.tplants.2020.01.004 15 DixonD

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When to Delay Dose Escalation Hold your current retatrutide dose and don't escalate if you experience: Persistent nausea or vomiting (more than 3 days after injection) Severe constipation or diarrhea Significant injection site reactions Rapid weight loss (more than 3-4 lbs/week consistently) Signs of dehydration from GI symptoms It's acceptable to remain at a dose longer than 4 weeks if needed

Corresponding reductions in HbA1c are 1.5%, 1.8%, and 2.0%