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If youre trying to understand the difference between semaglutide and tirzepatide, the short answer is this: they work in similar ways, but tirzepatide activates an additional metabolic pathway, which often leads to greater weight loss for some people

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Cardiovascular Benefits: Semaglutide stands out as it significantly reduces major adverse cardiovascular events (MACE) by 26% in patients with type 2 diabetes (SUSTAIN-6) 2 and is the only weight loss medication approved to lower the risk of major cardiovascular events, such as death, heart attack, or stroke, in adults with known heart disease and obesity or overweight (SELECT) 3

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