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These are illustrative, not a contraindication checklist there is no contraindication table because there is no approved indication: Wilson's disease or other copper metabolism disorders GHK-Cu delivers copper systemically, and copper accumulation with chronic injectable use has not been characterized Glucose-6-phosphate dehydrogenase (G6PD) deficiency high-dose systemic ascorbic acid can precipitate hemolytic anemia in this population Active renal disease or nephrolithiasis ascorbic acid at systemic doses increases urinary oxalate excretion and oxalate stone formation risk Known hypersensitivity to any ingredient class injectable preparations in this class have produced severe cutaneous adverse reactions, including a reported case of Stevens-Johnson syndrome / toxic epidermal necrolysis following IV glutathione plus vitamin C infusion Pregnancy or breastfeeding safety data for injectable cosmetic preparations of this class in these populations does not exist Immunocompromised status compounded sterile injectable preparations carry documented contamination-related infection risk when pharmacy sterility standards are not maintained Intravenous route specifically IV glutathione has been characterized in systematic review literature as contraindicated due to insufficient efficacy evidence and adverse side-effect profile What to test before starting Because GLOW contains pharmacologically active compounds delivered systemically, baseline laboratory assessment is clinically appropriate before initiating any injectable cosmetic preparation

Int J Mol Sci (2019) 20(21):5407

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