Comparison between long-term and short-term impact of increased TMAO levels MI: myocardial infarction
However, under low-oxygen conditions, hydroxylation is inhibited, resulting in stabilized dimerization of HIF- with HIF- and subsequent binding to numerous target genes to initiate the transcriptional activation of key factors, such as erythropoietin (EPO), hemoglobin (HB), and vascular endothelial growth factor (VEGF) ( Figure 2 illustrates the regulation of HIF in response to hypoxic conditions
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