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Importantly, these medications carry a boxed warning and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

SIMI is primarily characterized by myocardial ischemia and hypoxia, impaired contractile function, and reduced left ventricular ejection fraction, leading to inadequate tissue and organ perfusion (104,105)

For the body, Sculptra may be considered in select areas where collagen stimulation supports the goal

Studies on the impact of GLP-1 agonists in psoriatic patients with type 2 diabetes and/or obesity, suggest benefit, but these trials are very small and as yet do not allow of any firm conclusions

Peptides are chemically synthesized by the condensation reaction of the carboxyl group of one amino acid to the amino group of another

Alongside prescribing, patients receive structured weight management support, including a clinical assessment, information about treatment, and ongoing check-ins while using the medication