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That is a powerful mechanism

This means oral supplementation with crystalline B12 can be effective even when food-bound B12 absorption is impaired

Which means in those disease states, and aging, this metabolic leak gets worse

Stress can contribute to poor nutrition or impairing digestion and absorption over time, while alcohol abuse interferes with absorption in the digestive system and damages the stomach lining ( 5 ) ( 6 )

The recommendation is to take between 25100 micrograms per day, as this amount has been shown to maintain healthy levels of vitamin B12 levels in older people