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Tirzepatide primarily targets GLP-1 and GIP receptors, while retatrutide also activates glucagon receptors

For type 2 diabetes, options include Ozempic (semaglutide), Rybelsus (oral semaglutide), Trulicity (dulaglutide), Victoza (liraglutide), Bydureon (exenatide), and Lyxumia (lixisenatide)

Nature 2011

The concept has precedent in other therapeutic areas

Neurochem Res 40:25272543 Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, Ferriero DM, Guillet R, Gunn AJ, Hagberg H, Hirtz D, Inder TE, Jacobs SE, Jenkins D, Juul S, Laptook AR, Lucey JF, Maze M, Palmer C, Papile L, Pfister RH, Robertson NJ, Rutherford M, Shankaran S, Silverstein FS, Soll RF, Thoresen M, Walsh WF (2011) Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop

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