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The recurring interplay of oxidative stress, inflammatory activation, and disrupted cellular signalling provides a unifying mechanistic framework linking renal, musculoskeletal, cutaneous, immunological, respiratory, gastrointestinal, and reproductive dysfunctions to those already described in cardiovascular, hepatic, and gonadal tissues (83)
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Targets amylin + GLP-1 receptors for complementary appetite suppression, gastric emptying delay, and leptin resensitization
Understanding these similarities and differences is critical for developing targeted interventions for substance abuse
Limiting high-fiber and gas-producing foods during symptomatic periods can provide relief
