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International Journal of Molecular Science

Oxyntomodulin reduces food intake and increases energy expenditure, leading to significant weight loss in a 28-day clinical study in human volunteers over 28 days [34], and has been shown to improve insulin secretion in short-term clinical studies in people with diabetes [35]

GLP-1R agonism causes a small rise (usually 23 bpm) in heart rate (149), GIP infusion increases heart rate in humans (60) and GCGR agonism appears to have a positive chronotropic and inotropic action on the heart (150)

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"Triple-Hormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial." New England Journal of Medicine