Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions
R.SreedharT
Because thyroid hormone synthesis by thyroid peroxidase (TPO) requires hydrogen peroxide (H2O2), adequate glutathione is needed to neutralise excess reactive oxygen species and protect thyroid follicular cells from oxidative damage and immune-mediated inflammation
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