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For type 2 diabetes, GLP-1 medications can be prescribed long-term if clinically appropriate

Some clinicians may use semaglutide off-label in selected patients for metabolic support, such as insulin resistance or weight reduction when other approaches have not worked

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Researchers have studied an oral version of semaglutide along with another GLP-1 drug, orforglipron (brand name Foundayo), for weight loss