semaglutide no longer working GLP-1 drugs work while you're on them. The problem is what happens when you stop. Clinical trials show two-thirds of people regain the weight within a year of stopping — and Why Tirzepatide Works When Semaglutide

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Eli Lilly $LLY stock rose 4.4% in premarket trading on Monday after full Phase 3 trial results for its experimental weight loss drug retatrutide showed participants on the highest dose losing an average of 28.3% of their body weight over 80 weeks.

(And unlike the name, it's actually easy to take

Before initiating therapy, the prescriber should confirm the diagnosis using CDC BMI-for-age percentile charts [7], screen for secondary causes of obesity (hypothyroidism, Cushing syndrome, genetic obesity syndromes), and obtain baseline labs including fasting glucose, HbA1c, lipid panel, hepatic function, and thyroid function

In the absence of any negative findings from the research and utilization of GLP-1s, the demand for this class of drugs will likely continue to increase, potentially resulting in a significant cost burden for the economy